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Urticaria Pigmentosa. Presented by Dr. C. J. Lunsford.
Mrs. M. K., aged 70, was first seen in August, 1930. She complained of "small hives" around her waist and abdomen. These were first noted in May, 1930. There had been only an occasional mild pruritus. No illness or infection preceded the onset of the condition. She had taken bromides for about one year prior to the onset but none during the last month. Her mouth was edentulous, and her tonsils appeared normal.Around the waist and on the abdomen, thighs and back there were small brown maculopapules. When rubbed they became slightly redder and occasionally slightly urticarial. Histopathologic observations were those of an extremely dense infiltrate of large cells in the subpapillary region, rather sharply defined from the reticular layer. When stained with Unna's polychrome methylene blue these were seen to be mast cells. One unusual feature was the extremely dense
Clarke T, Templeton HJ. SAN FRANCISCO DERMATOLOGICAL SOCIETY. Arch Derm Syphilol. 1931;23(2):397–400. doi:10.1001/archderm.1931.03880200187019