Increase in the protein content of the cerebrospinal fluid is probably the earliest and the most constant of the abnormalities noted in the fluid under pathologic conditions. The presence of increased amounts of protein constitutes direct evidence of a definite reaction of fundamental importance, rendering diagnosis more accurate.
Hewitt1 Kafka and Samson,2 Reznikoff,3 Neel,4 Lange5 and others stated that an increase of protein above the normal is invariably accompanied by an increase of the globulins, and that this increase ordinarily is accompanied by positive Wassermann and colloidal reactions. The globulin fraction and its relation to the Wassermann and colloidal reactions will be discussed more fully in this report.
Kafka and Samson2 maintained that in every case in which there is a positive Wassermann reaction of the spinal fluid, there is also an alteration in the protein content of the fluid. In
SPIEGEL L. THE SPINAL FLUID IN SYPHILISTHE CLINICAL SIGNIFICANCE OF THE TOTAL PROTEIN AND GLOBULIN A PRELIMINARY REPORT. Arch Derm Syphilol. 1932;25(6):1071–1096. doi:10.1001/archderm.1932.01450021107013