This clinical study of 500 cases of neurosyphilis was undertaken in an attempt to determine the influence that modern treatment of syphilis plays in the production of neurosyphilis. The literature contains many references to the relationship of modern treatment to this serious complication of the nervous system. Finger,1 as early as 1910, mentioned the possible danger of injury to the nervous system by the use of arsphenamine. Ehrlich2 felt that neurorecurrences were attributable to incomplete sterilization of Spirochaeta pallida, and that specific treatment prevented the development of a defensive mechanism against any of the organisms that may have lurked in some isolated and walled off spirochetal nest.
Many other writers have considered inadequate early treatment as a paramount factor in the development of neurorecurrences; among these are Pette,3 Bernard and Ruelle,4 Zimmerman,5 Scholtz and Willmer,6
O'LEARY PA, ROGIN JR. THE ARSPHENAMINES AS FACTORS IN THE PRODUCTION OF NEUROSYPHILIS. Arch Derm Syphilol. 1932;26(5):783–796. doi:10.1001/archderm.1932.01450030784001