Our purpose in this paper is to report the clinical record and autopsy observations in a fatal case of meningitis due to Endomyces capsulatus, occurring in a man. who had had a typical blastomycetic dermatitis for three years. The organism was recovered during life from the spinal fluid, blood and urine. A study and description of the morphology, cultural characteristics and animal pathogenicity of the organism are included. A review of the literature of systemic blastomycosis is presented, with special reference to involvement of the central nervous system.
Since Busse and Buschke1 first described a case of generalized infection with a yeastlike organism, there have been about sixty reports of systemic infections, most of them under the term ``blastomycosis.'' Gilchrist and Stokes2 were the first to describe cutaneous blastomycosis, and there are now over two hundred cases of ``blastomycetic dermatitis'' in the literature. In only a few
MacBRYDE CM, THOMPSON EI. LXII.—MENINGITIS AND DERMATITIS CAUSED BY A NEW VARIETY OF BLASTOMYCETE (ENDOMYCETE). Arch Derm Syphilol. 1933;27(1):49–69. doi:10.1001/archderm.1933.01450040052005