Diseases of the lymph nodes constitute an important phase of pathology, but despite careful study many of the reactions of lymphoid tissue are little understood.
In 1928, Michelson1 reported an investigation of the inguinal nodes in early syphilis in which he found microscopically two different types of reaction to the infection: banal or nonspecific inflammation and the tuberculoid type of reaction characterized by epithelioid and giant cells without necrosis. The latter structure was observed in the nodes of 8 of 29 patients with early untreated syphilis. The work was continued, and a second report2 was made in 1932, in which the histologic examinations of 145 lymph nodes from patients with early syphilis were reported, tuberculoid structure being found in 27 per cent of the cases.
It was believed that further study of this type might possibly throw some light on immunity in syphilis. This investigation was made in
LAYMON CW. TUBERCULOID REACTION IN LYMPH NODES. Arch Derm Syphilol. 1934;30(4):518–536. doi:10.1001/archderm.1934.01460160032006