The difficulties encountered in the treatment of dermatophytosis are well known. The obstinacy of the condition in some cases is at times distressing to the physician as well as to the patient. In many cases all forms of therapy are resisted, while in others a response is easily obtained to many varieties of treatment but there is a recurrence after a short interval. The large number of local remedies that have been suggested for dermatophytosis is excellent proof of the fact that the treatment is still largely empirical. A rational form of therapy is obviously needed for this common disease of the skin. If the cutaneous changes which occur in dermatophytids of the hands are caused by a reaction to the toxin emanating from the mycotic foci in the feet, it appears to be logical to attempt to desensitize the skin with gradually increasing doses of the offending agent.
TRAUB EF, TOLMACH JA. DERMATOPHYTOSISITS TREATMENT WITH TRICHOPHYTIN. Arch Derm Syphilol. 1935;32(3):413–421. doi:10.1001/archderm.1935.01470030055007