Vaccination with smallpox vaccine has been used for reccurrent herpes simplex in Europe for several years, but the treatment has had little publicity in America. When patients with recurrent herpes simplex are vaccinated with ordinary smallpox vaccine, the attack is shortened, and definite immunization to further attacks follows. Observations on thirty-five patients are presented in this paper; five had recurrences.
The effect of smallpox vaccination was first called to our attention in 1926, during an epidemic of smallpox in Los Angeles, when one of us (P. D. F.) had had attacks of herpes labialis so frequently that a white scar still remains. During the epidemic he was vaccinated approximately six times, and since that time no further attacks have occurred.
In the past ten years considerable scientific work has been done with filtrable viruses. The nature and physiologic properties of viruses are peculiar, and all visible criteria are new and
FOSTER PD, ABSHIER AB. SMALLPOX VACCINE IN THE TREATMENT OF RECURRENT HERPES SIMPLEX. Arch Derm Syphilol. 1937;36(2):294–301. doi:10.1001/archderm.1937.01480020050006