The proper selection of a blood donor necessitates not only tests for compatibility of blood and physical examinations but also, immediately before the transfusion, a very sensitive blood test for syphilis to prevent the transmission of this disease. The Kline exclusion slide test is an excellent method for this purpose, even in emergency cases, because of the rapidity, simplicity and ease of its performance and its high degree of sensitivity.
Fifty-nine cases1 in which syphilis has been transmitted by donors are already recorded in medical literature! The actual number is probably much greater. In most of the cases reported serologic and physical examinations of the donors either were not made at all or else were not made within from three to twelve weeks prior to the transfusion. Professional donors, especially those used in cases of emergency, usually fall in the latter category, while voluntary donors, especially friends and relatives,
STRAUS R. KLINE EXCLUSION TEST IN PREVENTION OF TRANSFUSION SYPHILIS. Arch Derm Syphilol. 1937;36(5):1039–1043. doi:10.1001/archderm.1937.01480050105014