In June 1935 the committee on evaluation of serodiagnostic tests for syphilis first reported1 on the frequency of positive reactions among patients with malaria. It will be recalled that the tests were performed by thirteen of the foremost serologists in America. A total of 457 tests of specimens from 36 malarial donors were studied, and there were 66, or 14.4 per cent, positive reactions and 6.1 per cent doubtful reactions. For only 14 of the 36 patients was there complete accord among the results obtained by the serologists. In tests that were repeated the results but rarely tallied with the original ones, some of the original reports being negative while repeated determinations were positive.
A second study recently completed included a total of 266 patients, with 4 tests made in most cases, for a total of 1,031 comparable tests. The tests were done by Hinton, Kline (using both diagnostic
HAZEN HH, SENEAR FE, PARRAN T, SANFORD AH, SIMPSON WM, VONDERLEHR RA. SEROLOGIC EVIDENCE OF SYPHILIS IN MALARIAL PATIENTS. Arch Derm Syphilol. 1938;37(3):431–440. doi:10.1001/archderm.1938.01480090060005