The need for a specific treatment for dermatophytosis arises from several factors. The disease is common; it is frequently obstinate; it is sometimes disabling; it predisposes to occupational dermatoses, and it tends to recur. General physicians as well as dermatologists are confronted with the problem in their practices.
The causal relation, in many cases, between ordinary fungous infections of the feet and secondary eruptions on the hands and other parts of the body has been established to the satisfaction of most dermatologists. The fact that the blood stream may be invaded has been demonstrated on a few occasions. The altered reactivity of the skin in these infections and the specificity of the trichophytin test are generally accepted.
With such bases, it is obvious that treatment should have been approached along immunologic lines. The first steps in this direction were taken with the idea of desensitizing the skin. The secondary eruptions
TOLMACH JA, TRAUB EF. TREATMENT OF DERMATOPHYTOSIS WITH VACCINES. Arch Derm Syphilol. 1938;38(6):925–929. doi:10.1001/archderm.1938.01480180091010