Much progress has been made in the study of sarcoid since Boeck1 revealed this clinical entity. In addition to Boeck2 dermatologists are indebted to Jüngling,3 Schaumann,4 Kuznitzky and Bittorf,5 Kyrle,6 Jadassohn7 and many others for the attainment of a sound understanding of this disease.
It has been shown repeatedly8 that the cutaneous eruption is merely a visible indication of a systemic disease, the tubercle bacillus being the most likely inciting agent. Kyrle's6b success in demonstrating the presence of the tubercle bacillus in the early efflorescences in the banal inflammatory response and its gradual disappearance simultaneous with the onset of a tuberculoid histologic structure in mature lesions is undeniable evidence of tuberculous causation. These observations were confirmed by Ruete.9 It thus became evident that the local immunologic response was capable of altering or destroying the micro-organism and hence preventing its detection
IRGANG S. SARCOID OF BOECKREPORT OF A CASE OF GENERALIZED CUTANEOUS DISTRIBUTION AND PULMONARY INVOLVEMENT, WITH CLINICAL CURE WITH TUBERCULIN. Arch Derm Syphilol. 1939;40(1):35–44. doi:10.1001/archderm.1939.01490010038005