To even the casual observer it is apparent that acne vulgaris must have some basic relation to the endocrine glands. Much has been written regarding this relation, but no one has as yet shown what it is. Only a few worthy experimental studies attempting to explore this sector are recorded, although a much larger number of essays tell of the therapeutic uses of a number of glandular products. Almost every time a new extract is made available, it is given an early trial in the treatment of acne. None of these products thus far has seemed effective.
Several authors1 have recorded their experiences with the use of androgen for acne. Their opinions as to its effectiveness have differed somewhat. Moreover, none of the reports has been on a sufficiently large number of patients to furnish evidence outweighing the uncertainties attached to results of treatment of a dermatosis marked by
CORNBLEET T, BARNES B. THE HORMONES AND ACNE VULGARISI. URINARY ASSAY FOR AND THERAPEUTIC USE OF ANDROGEN. Arch Derm Syphilol. 1939;40(2):249–252. doi:10.1001/archderm.1939.01490020076009