The advent of any new drug creates the necessity of being alert to a complicating eruption.
While the possibility of a sulfanilamide eruption is well known, I have found only casual reference in the American literature to dermatitis caused by sulfapyridine. Therefore, the following report is made.
REPORT OF CASES
T. L., a white boy aged 13, was admitted to the medical service of Dr. Edward W. Parsons at St. Vincent Charity Hospital on Feb. 5, 1940, because of a cold and cough. Six days later a diagnosis of pneumonia was made (no specific type), at which time sulfapyridine was ordered, 15 grains (1 Gm.) every four hours. On February 18, one week after administration of the drug, a morbilliform eruption appeared. This rash was generalized, symmetric and macular. On the face and trunk it was almost solid and there was dusky erythema, while on the abdomen and
LaRocco CG. SULFAPYRIDINE DERMATITISReport of Two Cases. Arch Derm Syphilol. 1940;42(2):341–342. doi:10.1001/archderm.1940.01490140105019