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Article
January 1943

STUDIES ON OINTMENTSII. OINTMENTS CONTAINING SALICYLIC ACID

Author Affiliations

MINNEAPOLIS

From the Division of Dermatology and Syphilology, University of Minnesota, H. E. Michelson, M.D., Director, and the Department of Dermatology and Syphilology, Minneapolis General Hospital, S. E. Sweitzer, M.D., Chief.

Arch Derm Syphilol. 1943;47(1):16-26. doi:10.1001/archderm.1943.01500190019002
Abstract

The first part1 of my studies on ointments dealt with the penetration of fifteen bases into the intact human skin. The present report is a continuation of these studies.

Salicylic acid was synthetically produced from phenol in the year 1860 by Kolbe and Lautermann,2 and Kolbe devised a commercially practical synthetic process in 1874.

Salicylic acid is an orthooxybenzoic acid.The first part1 of my studies on ointments dealt with the penetration of fifteen bases into the intact human skin. The present report is a continuation of these studies. Only the orthobenzoic acid has pharmacologic action; the metabenzoic and parabenzoic acids are pharmacologically inactive.The solubility of salicylic acid is, according to Moncorps,3 as follows: One part of salicylic acid dissolves in 13 parts of boiling water, in 444 parts of water at a temperature of 15 C., in 500 parts of water at 20 C., in 60 parts of glycerin, in 45 parts of olive oil and in 7 parts of castor oil.

The antiseptic action of salicylic acid is about equivalent to that of phenol.

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