The first part1 of my studies on ointments dealt with the penetration of fifteen bases into the intact human skin. The present report is a continuation of these studies.
Salicylic acid was synthetically produced from phenol in the year 1860 by Kolbe and Lautermann,2 and Kolbe devised a commercially practical synthetic process in 1874.
Salicylic acid is an orthooxybenzoic acid. Only the orthobenzoic acid has pharmacologic action; the metabenzoic and parabenzoic acids are pharmacologically inactive.The solubility of salicylic acid is, according to Moncorps,3 as follows: One part of salicylic acid dissolves in 13 parts of boiling water, in 444 parts of water at a temperature of 15 C., in 500 parts of water at 20 C., in 60 parts of glycerin, in 45 parts of olive oil and in 7 parts of castor oil.
The antiseptic action of salicylic acid is about equivalent to that of phenol.
STRAKOSCH EA. STUDIES ON OINTMENTSII. OINTMENTS CONTAINING SALICYLIC ACID. Arch Derm Syphilol. 1943;47(1):16–26. doi:10.1001/archderm.1943.01500190019002