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Article
April 1943

RAPID TREATMENT OF EARLY SYPHILISREPORT OF TWO HUNDRED AND EIGHTY TREATMENT COURSES WITH MAPHARSEN ALONE AND FIVE HUNDRED AND FORTY-NINE TREATMENT COURSES WITH MAPHARSEN COMBINED WITH FEVER

Author Affiliations

NEW YORK

From the Department of Dermatology and Syphilology, New York University College of Medicine, and the Department of Dermatology and Syphilology, Third Medical Division (New York University), Bellevue Hospital.

Arch Derm Syphilol. 1943;47(4):553-568. doi:10.1001/archderm.1943.01500220091008
Abstract

In 1941 we made a first report1 on the rapid treatment of early syphilis by a course of diurnal injections of mapharsen, either alone or combined with fever therapy. By June 1942 in Bellevue Hospital 829 such courses had been given. As 47 of those were retreatments of patients who either had not been cured by their first course or had been reinfected, we treated a total of 782 patients. Of these, 479 were male and 303 female, and 462 were Negroes, 283 white persons, 35 Puerto Ricans and 2 Chinese.

METHODS OF TREATMENT AND CHOICE OF PATIENTS  Originally we set out to give every patient a total of 1.2 Gm. of mapharsen. As we reported, we did not administer the drug by the intravenous drip method introduced by Chargin, Leifer and Hyman.2 Instead, we gave 0.06 Gm. of mapharsen intravenously every morning and evening for ten days.

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