The use of urea (carbamide) has been applied to a wide variety of medical conditions in the past ten years. It has been employed most frequently in the treatment of infections, particularly infected wounds and ulcers, infections of the ears, infected tooth sockets and infected malignant growths, and of burns. It has been recommended also for the treatment of scar tissue, for the eradication of warts and even as a preventive against dental caries.
Synthetic urea is readily available, it is stable, soluble in water and easily incorporated into solutions, lotions, ointment bases and dusting powders. It apparently is nontoxic when absorbed and nonirritating when applied to wounds, and it has the added advantage of being inexpensive. It would seem, therefore, to be a suitable ingredient for a hand cream, for it incorporates into a special kind of cosmetic a drug that, while useful, is free from
RATTNER H. USE OF UREA IN HAND CREAMS. Arch Derm Syphilol. 1943;48(1):47–49. doi:10.1001/archderm.1943.01510010051007