Mahoney1 and Stokes,2 with their collaborators, have reported the occurrence of fever and abscess formation in persons undergoing treatment for syphilis with penicillin. The case presented here includes features not mentioned by those authors.
REPORT OF A CASE
J. M., a white man aged 40, when first seen, on Jan. 15, 1945, had a nodular ulcerative syphilid on the extensor aspect of the right forearm which had been present for two years. The physical condition was good, and a general examination revealed no other abnormalities. The Wassermann reaction of the blood was 4 plus, and complete fixation of the complement occurred with 0.2 cc. of cerebrospinal fluid.
Therapy was commenced with oxophenarsine hydrochloride (mapharsen) and a bismuth preparation.
Goebel ME, Grace AW. FEVER AND STERILE ABSCESS FORMATION ACCOMPANYING TREATMENT OF SYPHILIS WITH PENICILLIN. Arch Derm Syphilol. 1945;52(5):399–400. doi:10.1001/archderm.1945.01510290104021