FROM October 1943, 730 patients with early syphilis have been treated with penicillin at the University Hospitals and City Hospital in Cleveland. In addition, a number of patients with syphilis of the central nervous system have been treated, but their cases have not been incorporated in this report. Moreover, many of these patients have been retreated since and a good many a second time, with progressively larger doses of penicillin as indications warranted.
ROUTINE IN USE OF PENICILLIN
All the patients studied were given careful physical examinations on admission and thereafter as indicated. With any open lesions, dark field examinations were made every few hours at first—as many as were necessary to study the disappearance of treponemas. Serologic examinations of the blood were made frequently.
At the University Hospital progressive dilutions are made on serums showing a reading of 1 plus on the Kline diagnostic test and 3
COLE HN, AYRES S, BARR JH, GENATIOS T, HELD B, MURPHY WW, PRINTZ DR, STRAUCH J, BINKLEY GW, COLIMODIO S, DRIVER JR, KILE RW, RAUSCHKOLB J. USE OF PENICILLIN IN THE TREATMENT OF SYPHILIS IN PREGNANCY. Arch Derm Syphilol. 1946;54(3):255–264. doi:10.1001/archderm.1946.01510380002001