GREAT strides have been made in the treatment of early syphilis with penicillin, and reports seem to bear out the belief that penicillin will be an important factor in the management of syphilis. Because of the dominant position assumed by penicillin in the treatment of syphilis, it is important to consider the reactions that may be encountered in the course of therapy. It has been found convenient to classify these reactions in two groups. The first group of reactions is caused directly by penicillin, and the second group of reactions is due indirectly to penicillin and consists in reactions to the products of destruction of the spirochetes.
On review of the literature in the consideration of the first group of reactions, that is, those due directly to penicillin, it is noted that although penicillin has been accepted as the most effective and least toxic chemotherapeutic agent widespread use of this
FROMER S. REACTIONS IN THE TREATMENT OF SYPHILIS WITH PENICILLIN. Arch Derm Syphilol. 1947;55(3):385–390. doi:10.1001/archderm.1947.01520030078012