STUDIES bearing on penicillin in the treatment of experimental syphilis of rabbits are of value in relation to the treatment of human syphilis, as has been found true of the organic arsenical and bismuth compounds. Not only are the clinical effects of the compound on acute testicular and cutaneous lesions and on spirochetes in these lesions readily observed by means of dark field examinations, but dosage in relation to complete or biologic cure may be determined with a fair degree of accuracy by means of transfer of lymph nodes.
It is true that the total dosage of penicillin per kilogram of weight required for the biologic cure of acute testicular syphilis of rabbits is much less than that required for the treatment of early syphilis of human beings. However, valuable information may be gained in relation to methods of administration, the relative therapeutic effectiveness of penicillins F, G,
KOLMER JA, RULE AM. PENICILLIN IN THE TREATMENT OF EXPERIMENTAL SYPHILIS OF RABBITSI. The Therapeutic Activity of Penicillin in Single and Multiple Doses in Isotonic Solution of Sodium Chloride and Peanut Oil-Beeswax by Intramuscular Injection. Arch Derm Syphilol. 1947;55(6):741–748. doi:10.1001/archderm.1947.01520060003001