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July 1947

ACROKERATOSIS VERRUCIFORMIS (HOPF)Report of Fourteen Cases in One Family in Four Generations, with a Review of the Literature

Author Affiliations


Arch Derm Syphilol. 1947;56(1):48-63. doi:10.1001/archderm.1947.01520070051005

IN A RECENT study of a wartlike eruption of the hands and feet in a boy of 17 years, investigation revealed a familial incidence of the disease involving no less than 14 members of the family in four generations. Careful histologic examination of the lesions seemed to warrant a diagnosis of Hopf's acrokeratosis verruciformis.


History.—  P.P.D., a 17 year old boy of Italian parentage, consulted me for warts on his hands (fig. 1), which, according to the boy's mother, had made their appearance when he was 9 months of age. He also presented acne vulgaris of the face. The mother and his 2 sisters suffered from similar lesions (figs. 2 and 3), and still further investigation led to the discovery of no less than 14 members of this family afflicted in the same manner over four generations. The genetic history is shown in figure 4. In all

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