THE ORIGINAL work of Peters, Stocken and Thompson1 demonstrated the great effectiveness of BAL (2,3-dimercaptopropanol) in saving animals systemically poisoned by liquid lewisite and showed the unequivocal benefits which resulted when BAL was applied externally to the skin contaminated by lewisite. Soon after these facts had been established, other research workers began to investigate such immediate practical problems as that of developing stable BAL preparations for topical application to the human skin and eye. It soon became obvious that the vehicle in which BAL was dissolved or suspended played an important role in determining the biologic efficacy and the physical and chemical stability of BAL. For this reason a large number and variety of vehicles had to be prepared and subjected to careful study.
After several groups of investigators had completed a considerable amount of preliminary work on different vehicles and on the technics for their testing, a cooperative
SULZBERGER MB, BAER RL, KANOF A, LOWENBERG C. BIOLOGIC EVALUATION OF VEHICLES FOR EXTERNAL APPLICATION OF BAL. Arch Derm Syphilol. 1947;56(1):90–104. doi:10.1001/archderm.1947.01520070093008