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Article
June 1948

CONTACT DERMATITIS FROM THE TOPICAL APPLICATION OF STREPTOMYCIN OINTMENTReport of a Case

Author Affiliations

CINCINNATI

Bristol Fellow in Antibiotics.; From the Department of Dermatology and Syphilology of the College of Medicine of the University of Cincinnati.

Arch Derm Syphilol. 1948;57(6):1048-1050. doi:10.1001/archderm.1948.01520190127017
Abstract

Contact dermatitis from the topical application of streptomycin ointment has not yet been reported. This type of treatment with streptomycin is not employed extensively at the present time. Sulzberger and Baer1 have used streptomycin topically in otitis externa and cutaneous infections due to Pseudomonas aeruginosa and colon bacilli. Preliminary trials with ointment containing streptomycin in some 70 patients with a variety of dermatoses have elicited no evidence of dermatitis. Preliminary trials with attempts at the induction of eczematous hypersensitization with streptomycin have also been without results. A few patients had been treated with ointments containing penicillin and streptomycin. In 1 case eczematous dermatitis developed and was proved to be due to the streptomycin.

REPORT OF A CASE  A 69 year old white woman was admitted to the Service of Dermatology, Cincinnati General Hospital, because of severe superficial ulcerations and cellulitis of both lower extremities. These lesions were superimposed on bilateral

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