Lupus erythematosus has baffled and eluded the medical profession for over one hundred years. The first half of this period has been devoted mainly to the study of the various types of the disease. Kaposi recognized early that the condition is associated with constitutional symptoms. At the turn of the century Jadassohn called attention to the acute type of lupus erythematosus as a serious systemic disease. In recent years Libman and Sachs widened the conception of the syndrome. Their well studied cases, associated with visceral manifestations, especially indeterminate endocarditis, were later identified by Libman as of subacute lupus erythematosus. Careful studies by the Mount Sinai group and the Mayo Clinic group further amplified knowledge of the nature of the disease. Klemperer and Baehr stressed the collagenous changes as evidenced by fibrinoid degeneration.
For purposes of orientation in the present symposium we shall adhere to the accepted classification, which
SILVER H. LUPUS ERYTHEMATOSUSIntroduction to the Subject. Arch Derm Syphilol. 1950;61(6):887–888. doi:10.1001/archderm.1950.01530130005001