SENILE keratoses are probably the most commonly recognized forerunners of cutaneous cancer. I refer to the hyperkeratotic plaques which are typically barely elevated, gray-tan or pink, sandpaperlike to the touch, sometimes but not always covered by a firmly adherent scale and found almost exclusively on the sun-exposed skin surfaces of persons who are usually middle aged or older and frequently blue eyed or gray haired and of English, Irish or Scottish extraction. Series of cases have been reported in which as many as 25 per cent of such lesions have become carcinomas, usually of the squamous cell type.
This presentation, however, is not concerned with the diagnosis or prognosis of senile keratoses but with a method of treatment which has proved to be eminently satisfactory during the past three years and which can be recommended for its convenience and amazingly good cosmetic results. It is, of course, entirely too
HALL AF. TREATMENT OF SENILE KERATOSES WITH PODOPHYLLIN. Arch Derm Syphilol. 1950;62(3):362–369. doi:10.1001/archderm.1950.01530160014002