ANNOUNCEMENT of the dramatic effects of cortisone in the treatment of rheumatoid arthritis1 and the promise of beneficial influence in the so-called collagen diseases2 and conditions associated with allergy initiated the search for other compounds that might be equally effective without the undesirable side effects. This led to the production of "marisone,"3 a steroid complex of dry sterol conjugates that are separated from the estrogen conjugates present in the starting material. This product contains considerable amounts of the phenolic and neutral sterols derived from pregnant mare's urine and present as water-soluble conjugates. Study of the sterol conjugates shows that the ether-soluble fraction, after acid hydrolysis, has been partitioned into acidic, phenolic, and neutral fractions. The conjugates are present in the form of sulfates and glycuronides.
Jaros and Spielman,4 in their study of the value of this product in bronchial asthma, found it to be safe, nontoxic, and well-tolerated in large doses. It exerted a
DUEMLING WW, MILLMAN M. NATURAL STEROID COMPLEXEvaluation of Use in Collagen Diseases and Chronic Dermatoses. AMA Arch Derm Syphilol. 1952;65(3):327–333. doi:10.1001/archderm.1952.01530220068006