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Article
October 1952

INTRACUTANEOUS HYALURONIDASE ACTION IN NORMAL AND ROENTGEN-IRRADIATED RABBITSHistological Study

Author Affiliations

MONTGOMERY, ALA.

From the Department of Dermatology and Syphilology (Dr. Ray O. Noojin, Professor and Chairman), Medical College of Alabama, Birmingham, Ala.

AMA Arch Derm Syphilol. 1952;66(4):506-516. doi:10.1001/archderm.1952.01530290082011
Abstract

THE PURPOSE of this investigation is to study histologically the effect of hyaluronidase on the diffusion of India ink in normal and in roentgen-irradiated cutaneous tissue of the rabbit.

The average spread of India ink with hyaluronidase was demonstrated to be 3.9 times greater than that of the India ink controls in a previous investigation of the biological effect of roentgen therapy.1 It was further demonstrated that this spread was not significantly altered by roentgen irradiation administered prior to the injection of India ink and hyaluronidase. Those injection sites were removed for histologic examination and provided the material for this investigation. A microscopic study of the injected tissue was essential to determine whether or not histologic changes existed that were not grossly reflected in the spreading action of India ink.

In 1928 Duran-Reynals initiated an investigation of the spreading factors by demonstrating the enhancing effect of testicular

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