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April 1953


AMA Arch Derm Syphilol. 1953;67(4):419-424. doi:10.1001/archderm.1953.01540040077012

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Subacute Lupus Erythematosus with a Favorable Response to Quinine. Presented by Dr. Samuel J. Zakon and (by invitation) Dr. Bernard J. Pass.


Dr. Stephen Rothman: I learned from Dr. Samuel Becker to treat patients with lupus erythematosus with quinine, starting with a dose of ½ grain (0.03 gm.) of quinine sulfate three times a day and increasing it up to 2 grains (0.13 gm.) three times a day. While we know lupus erythematosus runs a very changeable course, it is my definite impression that quinine is very effective in the symptomatic treatment of disseminated lupus erythematosus. I should like to ask Dr. Becker where this treatment originated and what is its rationale?

Dr. Samuel Becker: I do not know the rationale of quinine treatment. I got it from Stokes at the Mayo Clinic, and I suppose he got it from Dr. Pusey or Dr. Wile. It is in the

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