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Article
May 1953

USE OF PODOPHYLLIN (PODOPHYLLUM RESIN) IN DERMATOLOGY

Author Affiliations

SANTA BARBARA, CALIF.

AMA Arch Derm Syphilol. 1953;67(5):488-495. doi:10.1001/archderm.1953.01540050052011
Abstract

THE PURGATIVE properties of podophyllum peltatum (May apple root) were known to the American Indian before the time of the white man.1 Its local use was recommended as early as 1861 for the treatment of "fungus growths," combined with zinc sulfate and hydrastine in the treatment of "cancerous growths," and because of its contrairritative action it was used in "chronic and obstinate cases of local neuralgic pain, spinal irritation, chronic hepatitis, pleuritis, synovitis, morbus coxaruis, etc."2

Although Kittredge3 has stated that the local application of podophyllin podophyllum resin has long been used in New Orleans in the treatment of condylomata acuminata, it was not until the report of Kaplan4 that this form of therapy became a matter of record. Subsequent reports have firmly established its value.5

The treatment of verruca vulgaris has not been so successful.6 Juvenile warts have occasionally been treated

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