THE ROLE of pyogenic bacteria in the production of acne pustules has evoked considerable discussion among dermatologists, and there is a wide divergence of opinion concerning its importance. Comparative studies reveal that most authors agree that the management of the recurrent cystic and large indurated acne lesions presents a therapeutic challenge. In Becker's series of 65 patients he performed bacteriologic studies and recovered hemolytic Staphylococcus albus in 7, nonhemolytic Staphylococcus albus in 25, hemolytic Staphylococcus aureus in 3, nonhemolytic Staphylococcus aureus in 12, a mixed growth of bacteria in 8, and no growth in the remaining 10. Sensitivity tests indicated that the organisms were more highly sensitive to penicillin than to the other antibiotics; however, clinical tests did not support these findings.
Sulzberger and Baer reported excellent results with local injections of aqueous solutions of penicillin and of bacitracin directly into the cystic lesions after aspiration of the
ROBINSON HM. ROLE OF ANTIBIOTICS IN THERAPY OF ACNE. AMA Arch Derm Syphilol. 1954;69(4):414–417. doi:10.1001/archderm.1954.01540160016003