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Article
May 1955

CLINICAL EVALUATION OF FIVE-TENTHS PER CENT HYDROCORTISONE OINTMENT

Author Affiliations

Brooklyn; Queens; Brooklyn

From the Division of Dermatology and Syphilology, Department of Medicine, State University of New York College of Medicine at New York City.

AMA Arch Derm. 1955;71(5):637-638. doi:10.1001/archderm.1955.01540290077020
Abstract

Hydrocortisone has now been established as an effective medication for topical use in many dermatologic conditions.* Most investigators have reported on the value of a 1% concentration of hydrocortisone acetate and have stated that concentrations below 1% were of no value.† It has recently been shown,‡ however, that the free alcohol of hydrocortisone is more effective topically than the hydrocortisone acetate. Accordingly, an ointment containing a concentration of a 0.5% hydrocortisone free alcohol was clinically evaluated and compared with the same ointment in a 1% concentration. Our results showed that a 0.5% hydrocortisone free alcohol ointment is a useful and effective medication topically.

METHODS AND MATERIALS

Two hundred eighty-two patients were treated with two ointments containing a concentration of 0.5% hydrocortisone free alcohol and 1% hydrocortisone free alcohol.

Wherever possible, contralateral areas were treated with each ointment for comparative evaluation.

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