The Ehlers-Danlos syndrome is a welldefined and distinct clinical entity.1 As its leading symptoms are cutaneous and its impediment appears at a time when children start to walk, most of the information on it appears in the dermatological and pediatric literature.* Only a few reports have been published in journals of more general interest †; however, the disease is neither particularly a pediatric nor a dermatological one. It is thought of by most authors as a general developmental disturbance of the mesenchyme. The etiology is probably based on a germ plasma mutation, as emphasized by its hereditary and familial tendency and frequent coexistence with other congenital anomalies.10
The main constituent features or signs, not all of which need to be present in the same case, are in short10 as follows:
Hyperelasticity of the skin.
Hyperextensibility of joints.
Skin friability, especially over bony prominences as
LEWITUS Z. Ehlers-Danlos SyndromeReport of Two Cases with Hypophyseal Dysfunction. AMA Arch Derm. 1956;73(2):158–161. doi:10.1001/archderm.1956.01550020058008