Amodiaquin (Camoquin), first synthesized in 1946 by Burckhalter and associates,1 is one of the 4-aminoquinolines, a group of compounds discovered after the development of quinacrine (Atabrine). Extensive investigations in the period 1946 to 1954 with these compounds, particularly chloraquine and amodiaquin, firmly established their value in the suppressive treatment of vivax and falciparum malaria.2 The value of chloroquine and quinacrine in the treatment of discoid lupus erythematosus is well established and need not be reviewed.
Having almost simultaneously encountered two patients with chronic discoid lupus erythematosus who failed to respond to quinacrine and chloroquine therapy, we decided to try amodiaquin, since a small supply was available to one of us (R. B. P.) through a local pharmacy. The results in these and in subsequent patients were very gratifying, thus prompting this preliminary report.
Report of Cases
Case 1.—A 31-year-old white woman was
PAPPENFORT RB, LOCKWOOD JH. Amodiaquin (Camoquin) in the Treatment of Chronic Discoid Lupus ErythematosusPreliminary Report, with Special Reference to the Successful Response of Patients Resistant to Other Antimalarial Drugs. AMA Arch Derm. 1956;74(4):384–386. doi:10.1001/archderm.1956.01550100052009