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Pemphigus Vulgaris; Duodenal Ulcer; Osteoporosis of Lumbosacral Vertebrae; Bronchial Asthma. Presented by Dr. Jesse A. Tolmach for Dr. Thelma G. Warshaw.
History: A 67-year-old woman was admitted to Beth Israel Hospital on Nov. 8, 1955, with an 18-year history of bronchial asthma and a 2½-year history of pemphigus vulgaris. She was treated with cortisone and ACTH, and a clinical remission followed. Eight months ago, steroids were stopped, and there was a relapse. Steroid treatment was reinstituted, and remission again resulted.
Two months before admission the patient developed low-back pain that radiated bilaterally, persistent epigastric pain, and a productive cough.
Dr. Beatrice Kesten: We have the tiger by the tail. We improve the pemphigus, change the patient, and produce other diseases. One can expect 10% to 15% to develop osteoporosis and peptic ulcer while on prolonged corticosteroid therapy, regardless of which ones are given. The current theory on
Riordan TJ. NEW YORK ACADEMY OF MEDICINE, SECTION OF DERMATOLOGY AND SYPHILOLOGY. AMA Arch Derm. 1957;75(1):148–152. doi:10.1001/archderm.1957.01550130150026