At a recent informal meeting of a large group of internists who are leaders in the field of infectious diseases, held in connection with the Central Society for Clinical Research, unanimous concern over the increasing numbers of antibacterial agents packaged in combination for oral or intramuscular use was expressed.
The accompanying editorial was suggested at this meeting. While the American physicians owe a great debt of gratitude to the drug houses of this country for the quality of their products, there can be no question that the trend toward promotion of combination preparations of this type is a dangerous one. The reasons for this are outlined in the following combined statement. It is recognized that physicians have the opportunity to use combinations of single antibiotics in any way they think best, but availability of the scores of antibacterial products already put up in combinations decided upon by the manufacturer and not arranged for each individual patient will unquestionably lead to abuses if unchecked.
Rhoads PS. The Clinical Use of Antibiotics in Combination. AMA Arch Derm. 1957;76(1):1–3. doi:10.1001/archderm.1957.01550190003001