It would be a relatively easy task to discuss cutaneous enzymes and their physiological and biochemical functions because extensive and high quality work has been done in this field in the last decade. However, it is a very tough job that has been assigned to me by your program committee, namely, to discuss clinical applications of this recently acquired knowledge, because such applications just are not forthcoming as yet. I certainly do not intend to discuss therapeutic applications of enzymes, such as the use of hyaluronidase in keloids or the use of streptokinase and streptodornase in treatment of leg ulcers, because either these methods have been disappointing or they have nothing to do with cutaneous enzymes. However, I will try to relate some of our knowledge of enzymes to the pathogenesis of skin diseases, particularly to blister formation and to nutritional deficiency states.
In general, enzymology
ROTHMAN S. Clinical Implications of Skin Enzyme Systems. AMA Arch Derm. 1957;76(3):277–281. doi:10.1001/archderm.1957.01550210001001