The author's successful clearing of lesions of necrobiosis lipoidica diabeticorum1 by injections of hydrocortisone acetate prompted an 18-month clinical investigation into the effect of injecting hydrocortisone into other dermatologic lesions.
Several other investigators have reported their results following injection of hydrocortisone into skin lesions. Sullivan2 found that lesions of sarcoidosis responded better to injections of hydrocortisone than to cortisone. Zachariae and Zachariae3 reported improvement of Dupuytren's contracture and Peyronie's disease after injections of hydrocortisone acetate. J. Graham Smith4 also reported 50% improvement in one case of necrobiosis lipoidica diabeticorum after the local injection of hydrocortisone and cited three other instances of similar improvement. In one case of localized myxedema reported by Forsey and Anhalt5 injections of hydrocortisone cleared the lesions after hyaluronidase had failed; in another case, hydrocortisone and hyaluronidase used simultaneously cleared lesions which had resisted them when used separately. Buchholz
SAVITT LE. Injection of Hydrocortisone into Dermatologic Lesions. AMA Arch Derm. 1957;76(6):780–782. doi:10.1001/archderm.1957.01550240098021