In the past 50 years since Von Pirquet created the concept of allergy most studies in this field have dealt with finding etiologic factors, with various forms of allergic reactions and the mechanisms producing them, with methods for demonstrating allergic changes, and with procedures designed to diminish or abolish allergic hypersensitivity once it has been established. Although many basic problems remain to be solved, important progress has been made in these directions.
In recent years increasing interest has been focused on those factors which determine susceptibility to allergic sensitization. For example, the question has been posed as to whether methods can be developed to diminish susceptibility to sensitization or perhaps even to block its development entirely. Even though the findings thus far are to some extent contradictory and progress in this field has been very slow, it appears worthwhile to review some of the
BAER RL. Remarks on Prevention of Allergic Sensitization. AMA Arch Derm. 1958;77(6):682–685. doi:10.1001/archderm.1958.01560060048009