Primary Hypercholesteremia with Xanthomas of Skin and Tendons and Coronary Disease. Presented by Dr. Jud R. Scholtz and Dr. Craig Williamson.
This 13-year-old boy was first seen in April, 1957. He has had yellow nodules in the skin and tendons and pain in his chest on exertion since the age of 10. All signs and symptoms have increased in intensity in the past year. Lesions are now present on the eyelids, knees, elbows, interdigital webs of hands, and tendons of hands and feet.
Electrocardiographic evidence of severe posterior ischemia in Master's test was consistent with marked coronary insufficiency.
There are marked thrill and bruit over both carotids. Liver and spleen are not palpable.
At the age of 6 years, he had 30 cavities in his teeth. At the advice of his dentist, he has not eaten refined sugar for the past two years.
Biopsy of lesion on knee:
Becker SW, Kettenbach F. LOS ANGELES DERMATOLOGICAL SOCIETY. AMA Arch Derm. 1958;78(3):400–405. doi:10.1001/archderm.1958.01560090116027