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January 1960

Acne, Estrogens and Spermatozoa

Author Affiliations

Galveston, Texas

From the Department of Dermatology (J. Fred Mullins, Professor and Chairman), University of Texas Medical Branch.

AMA Arch Derm. 1960;81(1):53-58. doi:10.1001/archderm.1960.03730010057006

It has been demonstrated that estrogenic substances, given in sufficient amounts, will significantly decrease the amount of sebum produced by the sebaceous glands.1 A number of dermatologists have utilized female hormones to decrease the sebaceous activity and to aid in the therapy of cystic acne vulgaris.1-6 On several occasions, there have been references to a temporary or permanent decrease in spermatogenesis following the utilization of these substances and the question arises as to their safety.5-10

The purpose of this study was to give conjugated estrogenic substances (Premarin) to a group of normal men for a period of three months and to check carefully all components of the sperm count during this interval of time. Also, we checked for sideeffects from this estrogenic substance, as well as instituted placebos at the end of the three-month trial period. It was decided to carry all subjects on the true substance

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