Any discussion of the treatment of scleroderma should be prefaced with the remark that such treatment is most unsatisfactory under most circumstances. This general group of diseases is among the most difficult to treat and offers the greatest therapeutic challenge. The treatment of scleroderma has been characterized by an ever-changing spectrum of oral medication, injections, and surgical procedures.
The course of scleroderma is variable with periods of progression and remission despite supposedly definitive therapy. Except for the recent studies of Curtis and Jansen1 regarding the prognosis of localized scleroderma, little information is available on the course of untreated scleroderma. The enthusiasm for the particular therapy rarely has been assessed against the prognosis of the nontreated patient. It is with this knowledge in mind that we must evaluate some therapy currently in use.
Although in the past each form of scleroderma was considered a separate entity, today the various clinical
PERRY HO. Recent Treatment Programs for Generalized Scleroderma. Arch Dermatol. 1961;83(2):300–304. doi:10.1001/archderm.1961.01580080130014