The incidence of circumscribed myxedema has increased with the wider use of the radioactive iodine cocktail. A review of the literature shows this condition to be extremely resistant to therapy. No satisfactory method of treatment has been reported.
Two practically identical cases were seen in our office in May, 1960. Both were women in their late forties, with large plaques over both tibiae. The diagnosis had been confirmed by biopsy. Their history showed that the condition occurred following therapy with the radioactive cocktail, and had been present for about one year with no apparent change. They had been advised that therapy was useless.
Each individual nodule was injected with a few minims of triamcinolone acetonide (Kenalog*), containing 10 mg. per ml. The treatment was repeated after one week. On examination one month later, all nodules had disappeared; no elevation was present, and there was no atrophy at the sites of
JAMES APR. Therapy of Circumscribed Myxedema. Arch Dermatol. 1961;83(4):661. doi:10.1001/archderm.1961.01580100125021