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Lichen Sclerosus et Atrophicus. Presented by Dr. Julius E. Ginsberg and (by invitation) Dr. Marvin H. Goldblatt.
This 71-year-old, white, married female complains of a lesion on the anteromedial aspect of the left thigh for the last 2 years. This area is sometimes pruritic. She has a history of diabetes and takes 60 units of protamine zinc insulin (PZI) daily, and a hypertensive heart condition for which she is also taking medication. The lesion has increased in size and also has become hemorrhagic the last few months. This patient has plaques with shiny surfaces as well as areas of hypo- and hyperpigmentation. One also sees atrophic as well as hemorrhagic areas.Histopathologic specimens stained with hematoxylin and eosin and Van Gieson-orcein are available for microscopical examination. The salient features of the histopathologic slides are (1) pronounced subepidermal edema, (2) fibrosis of the deeper dermis, (3) minor keratotic plugging, (4)
Shellow H, Malkinson FD. CHICAGO DERMATOLOGICAL SOCIETY. Arch Dermatol. 1962;86(3):348–355. doi:10.1001/archderm.1962.01590090090021