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Article
November 1962

Method for Comparing Percutaneous Absorption of Steroids

Author Affiliations

LONDON; CLEVELAND

Fellow in Dermatology (Dr. McKenzie), Western Reserve University; Present address: St. Thomas' Hospital, London S.E.1, England; Director of Dermatology (Dr. Stoughton), Western Reserve University.

Arch Dermatol. 1962;86(5):608-610. doi:10.1001/archderm.1962.01590110044005
Abstract

A simple method for assessing the percutaneous absorption of steroid preparations is suggested.

Using vasoconstriction as an index of absorption, occlusion of the skin surface with Saran Wrap results in a 100-fold difference in absorption over simple topical application.

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