The chief significance of angioid streaks at the present time is their occurrence in conjunction with 3 disorders—pseudoxanthoma elasticum, Paget's disease of bone, and sicklecell disease. It appears unlikely that a fundamental relationship exists between these disorders, despite the occurrence of such distinctive lesions as angioid streaks with all three.
CAWLEY EP, WEARY PE. The Significance of Angioid Streaks. Arch Dermatol. 1962;86(6):725–728. doi:10.1001/archderm.1962.01590120023004