Granulomatous skin lesions associated with chronic infection by Candida albicans are manifestations of a rare and severe form of generalized mucocutaneous candidiasis. This syndrome is characterized by the appearance, in early childhood of extensive superficial candidiasis which runs a course of many years and tends to recur following treatment. The mouth, face, scalp, and fingernails are most commonly involved. Late in the disease granulomatous plaques develop on the skin—resembling those seen in the deep mycoses; however, no visceral involvement with Candida is present. Intravenous amphotericin B is the only effective form of therapy and has greatly improved the prognosis in this potentially fatal disease. The case reported presents typical Candida granulomas with associated widespread dermatophytosis due to Epidermophyton floccosum. In addition, this patient developed carcinoma of the esophagus, possibly as a result of long-standing esophageal candidiasis. The recent literature is reviewed and the cases reported to date summarized.
KUGELMAN TP, CRIPPS DJ, HARRELL ER. Candida Granuloma With EpidermophytosisReport of a Case and Review of the Literature. Arch Dermatol. 1963;88(2):150–157. doi:10.1001/archderm.1963.01590200038007