The biosynthesis, physiology, and pharmacology of progesterone and estrogen are briefly discussed.
A study on the absorption of estrogens by the skin when applied in the form of a cream containing 10,000 IU of estrogens and 5 mg progesterone per ounce was carried out on two sisters, aged 14 and 17, and a 35-year-old female with gonadal dysgenesis. It was concluded that the cream produced no significant local effects and the absorption was too minor to produce any systemic effect. More concentrated estrogen-progesterone cream containing 50,000 IU of estrogens and 25 mg of progesterone per ounce had significant local effects when applied to the vagina and vulvae of a 58-year-old woman with dyskeratotic lesions of the vulvae.
GREENBLATT RB, MAHESH VB, RIGAS LC, SHAPIRO ST. Physiologic and Clinical Aspects of Ovarian Hormones. Arch Dermatol. 1964;89(6):846–857. doi:10.1001/archderm.1964.01590300074022