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March 1965

Epidermolysis Bullosa AcquisitaA Disease of Dermal Connective Tissue

Author Affiliations


From the Division of Dermatology, University of Oregon Medical School.

Arch Dermatol. 1965;91(3):219-223. doi:10.1001/archderm.1965.01600090027004

A case of epidermolysis bullosa acquisita in a 62-year-old woman is presented. Histochemical studies show abnormalities of dermal connective tissue in both clinically involved and uninvolved skin. The most striking abnormality is an accumulation of acid mucopolysaccharides. Biochemical analysis of clinically uninvolved skin supports the histochemical findings and suggests that the accumulation is a sulfated mucopolysaccharide. The relationship of a generalized disease of the dermal connective tissue to certain clinical findings is discussed. Clinically and histologically, epidermolysis bullosa acquisita resembles the more common epidermolysis bullosa dystrophica.