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Article
August 1965

Myotonia and Keratoderma Induced by 20,25 Diazacholestenol

Author Affiliations

COLUMBIA, MO

From the Division of Dermatology and Cardiovascular Laboratory, University of Missouri Medical School, Columbia.

Arch Dermatol. 1965;92(2):181-183. doi:10.1001/archderm.1965.01600140069018
Abstract

A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, keratoderma climactericum. These observations further emphasize the importance of normal lipid synthesis in orderly cornification.

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