A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, keratoderma climactericum. These observations further emphasize the importance of normal lipid synthesis in orderly cornification.
ANDERSON PC, MARTT JM. Myotonia and Keratoderma Induced by 20,25 Diazacholestenol. Arch Dermatol. 1965;92(2):181–183. doi:10.1001/archderm.1965.01600140069018