A case of long-standing hyperglobulinemic purpura eventuating in xanthoma tuberosum, hyperlipidemia, and myeloma is presented. Laboratory studies disclosed marked elevations of serum cholesterol, triglycerides, fatty acids, and β2-globulin. Bone marrow examination confirmed the diagnosis of multiple myeloma. The causal relationship of the myeloma protein to the hyperlipidemia is discussed.
SAVIN RC. Hyperglobulinemic Purpura Terminating in Myeloma, Hyperlipemia, and Xanthomatosis. Arch Dermatol. 1965;92(6):679–686. doi:10.1001/archderm.1965.01600180071013